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Mediastinal germ cell tumor survivors

Kaplan-Meier plot of the (A) overall survival and (B) progression-free survival duration for 27 patients with mediastinal nonseminomatous germ-cell tumors. The median progression-free survival from diagnosis was 8.5 months for patients referred in relapse and was not estimable for the patients referred at diagnosis (log rank P < 0.001) Primary Mediastinal Germ Cell Tumor (PMGCT) is a rare and heterogeneous entity. These tumors are typically diagnosed in young adults and carry a poor prognosis. We conducted this study to evaluate the role of radiotherapy on treatment outcomes and prognostic factors in PMGCT that may allow a more adapted treatment strategy to improve survival hi everyone..i'm a ewbee here and also a cancer survivor of 20 some years.. now our oldest son has mediastinal Germ Cell Tumors, a rare version of cancer and he has it in the chest cavity as well as in his lymph glands..he is in a cancer treatment centre.he had devoloped some fluid around his heart .they think that it( the cncer) has penetrated the lining around his heart.and they have a. The worst pathology identified in the residual mediastinal mass after chemotherapy was necrosis in 61 patients (25.0%), teratoma in 84 patients (34.4%), and malignant (persistent germ cell or non-germ cell cancer) in 97 patients (39.8%), which influenced overall survival (P <.001) Germ Cell Tumor Survivor. I hope you are doing well. I am a survivor of a mixed-cell mediastinal germ cell tumor and I know how hard the treatment is. I know it is discouraging that there didn't seem to be much shrinking of the tumor. I was in the same place myself. By the time I was diagnosed, my tumor was really big and they really buried me.

Stephan D. Voss, in Oncology of Infancy and Childhood, 2009 Germ Cell Tumor. Mediastinal germ cell tumors are primarily located in the anterior mediastinum, near the thymus gland, and make up about 10% to 20% of all childhood mediastinal tumors. Germ cell tumors are second only to lymphoma as the cause of a thymic/anterior mediastinal mass Figure E1 Long-term survival in patients with primary mediastinal nonseminomatous germ cell tumors, including both operative survivors and operative deaths (within 30 days of surgery), based on the worst pathologic diagnosis microscopically identified in the residual mass (ie, necrosis, teratoma, or malignant)

Primary malignant mediastinal germ cell tumor (PMMGCT) is rare and sometimes the prognosis of the patients with PMMGCT is not very satisfactory. A total of 54 patients with PMMGCT in a follow-up from 1990 to 2009. We evaluated the role of the surgical treatment and the effect of multimodality treatment strategy for patients with PMMGCT. Fifty-two patients underwent surgical resections, while. of primary mediastinal nonsemi-nomatous germ cell tumors is important. Pre- and postchemo-therapy pathology as well as postoperative serum tumor markers are independent pre-dictors of long-term survival. PERSPECTIVE Primary mediastinal nonseminomatous germ cell tumors represent a rare but important malig-nancy, which occur in otherwise young an Germ cell: The majority of germ cell neoplasms (60 to 70%) are benign and are found in both males and females. Thyroid mass mediastinal: This is usually a benign growth, such as a goiter. Middle mediastinum. Bronchogenic cyst: This is a benign growth with respiratory origins. Lymphadenopathy mediastinal: This is an enlargement of the lymph nodes These tumors originate in the anterior mediastinum without any testis primary. Mediastinal nonseminomatous GCTs carry a poor prognosis with 40-50% overall survival and should be treated with cisplatin-based chemotherapy followed by surgical resection of the residual tumor

Primary mediastinal germ cell tumors: Survival outcomes

Prognosis worse than gonadal germ cell tumors; 5 year disease free survival is 50 - 65% for seminomas, 20% for other subtypes. Good prognostic factors for nonseminomatous tumors: rapid decline in serum AFP or hCG after surgery and chemotherapy, no vascular invasion, no yolk sac or choriocarcinoma components Most germ cell tumors will form in the sex organs (e.g., the testes), but they can develop anywhere in the body, including the mediastinum. Mesenchymal tumors develop from mesenchymal cells in the connective tissue. A sarcoma is a cancer of the mesenchymal cells. Symptoms. About half of all patients with mediastinal tumors will experience no. The records of 87 patients with primary mediastinal germ cell tumors who underwent primary treatment at 29 French centen from 1983 to 1990 were reviewed. This series was collected by a retrospective questionnaire completed on all the patients with mediastinal germ cell tumors seen and treated at the participating centers during the period of.

Primary mediastinal germ cell tumor (PMGCT) is a rare cancer that accounts for less than 5% of germ cell malignancies and only 1-4% of all mediastinal tumors [1, 2]. The histopathological characteristics of PMGCTs are similar to those of gonadal germ cell tumors (GCTs) If you're wondering what the reason why I go after a tonne of travel experiences via this silly travel blog, well this is it!. Hi, my name is Anthony Bianco and I live in Australia.. I am a long term primary mediastinal nonseminomatous germ cell tumour survivor.You've obviously come across this page because you're trying to find someone who has survived this extremely rare cancer, and. Intensive cisplatin-based chemotherapy followed by resection of residual tumor was shown to yield survival rates of 48-73% in nonseminomatous mediastinal germ cell tumors. Walsh et al reported on the experience at M.D. Anderson Cancer Center over 5 years with 20 patients treated for nonseminomatous mediastinal germ cell tumors Related narrative: Primary Mediastinal Non-Seminomatous Germ Cell Tumor This discussion will provide a concise overview of Primary Mediastinal Non-Seminomatous Germ Cell Tumors (PMNSGCT). A broad overview of testicular tumors is available in the testicular cancer discussion.. Extragonadal germ cell tumors arise in the anterior mediastinum or retroperitonuem and represent 15% of adult anterior.

The tumors are more frequent in individuals with Klinefelter syndrome and are associated with a risk of subsequent development of hematologic neoplasia that is not treatment related. [ 9, 10] Approximately 50% of patients with mediastinal nonseminomas will survive with appropriate management. [ 11 Malignant mediastinal germ cell tumors: an intergroup study. Eighteen patients had biopsy followed by chemotherapy and postchemotherapy tumor resection with 13 survivors. Tumor size in response to chemotherapy for these 18 patients was stable or increased in 6, and decreased in 12 (mean decrease of 57% in greatest dimension).. Bokemeyer C, Nichols CR, Droz JP, et al.: Extragonadal germ cell tumors of the mediastinum and retroperitoneum: results from an international analysis. J Clin Oncol 20 (7): 1864-73, 2002. [PUBMED Abstract] Kang CH, Kim YT, Jheon SH, et al.: Surgical treatment of malignant mediastinal nonseminomatous germ cell tumor Mixed germ cell tumors occur in many forms. Among these, a common form is teratoma with endodermal sinus tumor. Teratocarcinoma refers to a germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both. This kind of mixed germ cell tumor may be known simply as a teratoma with elements of embryonal carcinoma or choriocarcinoma, or simply by.

mediastinal Germ Cell Tumors Cancer Survivors Networ

Outcomes following surgery for primary mediastinal

Germ Cell Tumor Cancer Survivors Networ

  1. Abstract. Background: Primary mediastinal malignant germ cell tumors (GCTs) are rare and have a worse prognosis than their gonadal counterparts. Although multimodality treatment is a standard therapeutic strategy in mediastinal GCTs, the clinical implications of surgical intervention remain unclear
  2. All patients with an anterior mediastinal mass should have alpha-fetoprotein (AFP), β-human chorionic gonadotropin (β-HCG), and lactate dehydrogenase (LDH) levels drawn at the outset. The different types of germ cell histologies are shown in Figure 3. Figure 1a: Chest radiograph of mediastinal germ cell tumor
  3. According to Malagon and Montiel, 55 germ cell tumors account for 16% of mediastinal neoplasms in adults and between 19% and 25% in children. Mediastinal germ cell tumors are divided into prepubertal and postpubertal. In the prepubertal group only two types of germ cell tumors have been reported in the mediastinum: teratoma and yolk sac tumor
  4. Mixed germ cell tumor (MGCT) mainly occurs in young women's ovaries and men's testicles and rarely occurs outside the gonad. Fewer than 10 cases of mediastinal MGCT are available in PubMed, Embase, and other databases in English, while mediastinal MGCT with three pathological components, such as yolk sac tumor, immature teratoma, and embryonal carcinoma, has not been reported previously. A.
  5. Benign mediastinal germ cell tumors, or teratomas, are the most common type of mediastinal germ cell neoplasms.1 Primary mediastinal teratomas account for approximately 8% to 20% of anterior mediastinal neoplasms and up to 80% of mediastinal germ cell tumors. Although mediastinal germ cell tumors account for only 3% to 5% of all germ cell tumors, they are the most common extragonadal site for.

Primary mediastinal germ cell tumors are rare, accounting for approximately 1-3% of all germ cell tumors, 15% of all anterior mediastinal tumors in adults and 24% in children. Germ cell tumors with benign behavior are more common in females and children, while the vast majority of malignant mediastinal germ cell tumors occur in older. the International Germ Cell Consensus Collaborative Group (IGCCCG) just based on their origin in the mediastinum [2]. Though mediastinal seminomas have excellent cure rates and survival outcomes, primary mediastinal nonseminomatous germ cell tumours (PMNSGCTs) whic Mediastinal germ cell tumors (GCTs) are rare and encompass less than one fifth of all mediastinal neoplasms in adults and children. These tumors predominantly occur in men. Most mediastinal GCTs are located in the anterior mediastinum. The vast majority of mediastinal GCTs are considered primary mediastinal tumors; however, a metastatic process. For this review, a secondary analysis of clinical and operative findings in patients with primary site in the mediastinum was carried out. Results: Of the 38 children with malignant mediastinal germ cell tumors (MGCT), 36 had sufficient data to be included in this review. Thirty-four tumors were anterior mediastinal, 2 were intrapericardial The association between non seminomatous germ cell tumors (GCTs) and hematological malignancies of rare lineage has been described in the literature. In some of these cases there is evidence that the leukemia derives from a pluripotent primitive clone present in the original germ cell tumor. We present a highly unusual case of a 23-year-old man of South Asian origin with a history of.

Mediastinal Germ Cell Tumor - an overview ScienceDirect

Germ cell tumors occur most frequently in the gonad, but in rare cases, they occur in extragonadal locations, usually in or near the midline. A variety of extragonadal germ cell tumors are known. The most common site of extragonadal germ cell tumors is the anterior mediastinum, especially near or within the thymus gland. [] In adults, approximately 10-15% of mediastinal tumors are germ cell. BACKGROUND: Primary germ cell tumors (GCT) of the mediastinum share similar clinical and biologic characteristics, which are different from their testicular counterpart. The purpose of the current study was to review the authors' institutional experience of mediastinal GCT, emphasizing the clinical spectrum, time trends of treatment, and recent advances in therapeutic modalities for malignant GCT Download Citation | Mediastinal germ cell tumors | Primary mediastinal non seminomatous germ cells tumors have both worse prognosis and survival than other germ cells tumors do. However, high. Purpose: Primary mediastinal germ cell tumors (PMGCTs) are rare. The natural history and optimal treatment strategies still need to be defined. The aim of the study was to summarize the clinical characteristics, treatment outcomes, and prognostic factors of PMGCTs.Methods: Twenty-four patients with PMGCTs who were treated from December 2008 to January 2019 were evaluated retrospectively

Management of the primary malignant mediastinal germ cell

  1. antly within the anterior mediastinum and frequently present as a very large.
  2. omas are usually curable with chemotherapy alone, while mature teratomas are treated with surgery alone
  3. Mediastinal teratomas are germ cell tumors located in the anterior mediastinum, representing the most common extra-gonadal germ cell tumors.. Epidemiology. They account for approximately 15% of anterior mediastinal masses in adults and approximately 25% of anterior mediastinal masses in children. They are by far the most common mediastinal germ cell tumor, accounting for 50-70% of such tumors

Mediastinal Tumors: Causes, Symptoms, Diagnosis & Treatment

Nonseminomatous mediastinal germ cell tumors (NS-MGCTs) are faster growing and metastasize earlier than mediastinal seminomas. o Although their incidence peaks in the third decade, several cases have been reported in patients older than 60 years. o Patients with mediastinal germ cell tumors may present with (in decreasing order) chest pain (39%. In women, 30% of ovarian tumors originate from germ cells. Younger women, commonly patients under the age of 21, are more common. 60% of these ovarian tumors are germ cell in origin and a third of it is found to be malignant. In men, germ cell tumors occur most commonly after puberty and most of them develop to testicular cancer in the long run

The serum tumor markers HCG and α-fetoprotein are usually abnormal in patients with mediastinal nonseminomatous germ cell tumors. α-Fetoprotein is most frequently abnormal and is elevated either alone or in conjunction with HCG in approximately 80% of patients, whereas elevation of HCG occurs in only 30 to 35% of patients The most frequent site of extragonadal germ cell tumors is the mediastinum. The majority (80%) of mediastinal germ cell tumors are benign mature teratomas, which can be easily removed. Malignant germ cell tumors account for approximately 20% of all cases and are clinically classified into seminoma and non-seminomatous germ cell tumors Germ cell tumours (GCTs) are a heterogeneous group of neoplasms [1,2].They are predominantly midline tumours occurring from birth to late adulthood [].All are believed to arise from totipotent primordial germ cells and derivatives thereof [4,5].In childhood, ~50% are gonadal and ~50% extragonadal (~20% intracranial and ~30% extracranial), and clinical presentation depends on tumour site [1,6]

Epidemiology. They account for approximately 15% of anterior mediastinal masses in adults and approximately 25% of anterior mediastinal masses in children. They are by far the most common mediastinal germ cell tumor, accounting for 50-70% of such tumors 9.. The age of presentation is wide, but the typical presentation in adults is in the third or fourth decade (the 20s and 30s) In children, tumors are more common in the posterior mediastinum. These tumors often begin in the nerves and are noncancerous (benign). Most mediastinal tumors in adults occur in the anterior mediastinum. They are usually cancerous (malignant) lymphomas, germ cell tumors, or thymomas. These tumors are most common in middle aged and older adults The authors examined overall survival (OS) and progression-free survival (PFS) among 113 patients with primary mediastinal germ cell tumors at a high-volume institution. Serum tumor markers normalized in 74% of patients. Bleomycin was not associated with pulmonary complications

Extragonadal germ cell tumors: clinical presentation and

Recurrent Germ Cell Tumors: Let's Try to Cure Them All

Management of paediatric extracranial germ-cell tumours carries a unique set of challenges. Germ-cell tumours are a heterogeneous group of neoplasms that present across a wide age range and vary in site, histology, and clinical behaviour. Patients with germ-cell tumours are managed by a diverse array of specialists. Thus, staging, risk stratification, and treatment approaches for germ-cell. We retrospectively assessed treatment outcomes at a single institution. Materials and methods: We identified men seen at our institution from 1998 through 2005 for mediastinal germ-cell tumors. Medical records were reviewed for patient characteristics, histology, tumor markers, treatment, and survival outcome Q: How many different kinds of mediastinal tumors are there? A: Mediastinal tumors can be classified by location (anterior, middle, and posterior) or by benign versus malignant. An anterior mass is the most common, and it could represent a thymoma, a lymphoma, a germ cell tumor, or a thyroid mass Extragonadal germ cell tumors account for 2-5.7% of germ cell tumors (GCTs). Of these, primary mediastinal GCTs (PMGCTs) are responsible for 16-36% of cases. Given the rarity of these tumors, specific treatment strategies have not been well defined. We report our experience in treating these complex patients. In total, 318 men treated at our institution with chemotherapy for GCTs between. Mediastinal Germ Cell, Pineoblastoma, Hairy Cell Lymphoma, Medullogastoma, Uterine Pecoma, Small Lung, Neuroendocrine, Granulosa Cell Tumor, Rhabdomyosarcoma, Anaplastic Oligodentroglima, Small Cell Cervical, Appenendiceal Mucinous YA's have delayed cancer diagnosis & survival rate has not improved in over 20 years

Germ cell tumors account for approximately 12-15% of all anterior mediastinal tumors and of less than 0.5% of all thoracic tumors1. Germ cell tumors commonly occur in young men, mean age of 31 years1. Germ cell tumors can be further categorized as teratomas, seminomas and non-seminomatous germ cell tumors. Non Seminomatous Germ Cell Tumors. In contrast, the overall survival rate for patients with a seminomatous EGCT is 88%, with no difference between patients with mediastinal or retroperitoneal tumor location (median follow-up, 49 months; range, 4 to 193 months; respective 70 months; range, 1 to 211 months) Abstract. Germ cell tumors (GCTs) are the most common cancer in men between the ages of 15 and 40. Although most patients are cured, those with disease arising in the mediastinum have distinctly poor outcomes. One in every 17 patients with primary mediastinal nonseminomatous GCTs develop an incurable hematologic malignancy and prior data.

The most common extragonadal site of primary germ cell tumors is the anterior mediastinum. The most common histologic type of mediastinal germ cell tumor is mature teratoma, which is typically asymptomatic and incidentally discovered. Radiographically, these tumors appear as rounded, often lobulated masses; calcification may be seen Mature teratomas are the most common primary mediastinal germ cell tumor (60-70% of mediastinal germ cell tumors). These tumors contain tissue from at least two of the three germ cell layers. Although they do not usually cause symptoms, they may occasionally compress local structures, resulting in chest pain, cough, or shortness of breath Malignant mediastinal germ cell tumors are a rare disease and represent only 1% to 4% of all mediastinal tumors. Gonadal germ cell tumors are generally the most common type and constitute 90% of germ cell tumors. The mediastinum is the second most frequently affected area ahead of other extragonadal areas, which include the retroperitoneum, the sacrococcygeal area, and the central nervous system Germ-cell tumors are curable even in the presence of metastatic disease. 1-3 An international collaboration has established that metastatic germ-cell tumors can be classified into good. Mediastinal germ cell tumors present as an anterior mediastinal mass, often resulting in chest symptoms. Retroperitoneal germ cell tumors may present as a palpable abdominal mass or with back pain

It has been reported that 40 to 54% of patients with mediastinal non-seminomatous germ cell tumor treated with platinum-based chemotherapy followed by surgical resection achieved long-term disease-free survival, but patients who relapsed after initial treatment experienced dismal outcomes with only 10% long-term survival [5-7]. Therefore, it. In a series of 635 patients with extragonadal germ cell tumors, 17 patients developed hematologic malignancies at a median of 6 months after the extragonadal germ cell tumor was diagnosed. All hematologic neoplasms developed in the 287 patients with mediastinal nonseminomatous germ cell tumors, for a 2% incidence in this group Mediastinal tumors are rare. They are usually diagnosed in patients age 30 to 50 years, but they can develop at any age.The location and type of mediastinal tumor vary according the age of the patient. In children, the tumors usually are non-cancerous (benign), usually start in the nerves (neurogenic), and usually are in the back of the mediastinum

Primary germ cell tumors of the mediastinum are 1-2% of all germ cell tumors and 1-3.5% of mediastinal tumors, making it an exceedingly rare find [].Germ cell cancers are the most common malignancy found in 15-35 year old men with 5% of malignant tumors being extra-gonadal [].Gonadal and extra-gonadal tumors share similarities in that they are both found in young adult men, usually in the. Cytogenetic analysis of the primary mediastinal germ-cell tumor in this patient revealed a similar karyotype. 33 An isochromosome of (12p) is a characteristic karyotypic abnormality for all.

Germ cell tumors (GCTs) are a model of curable cancer, as most patients with metastatic GCTs are successfully treated with cisplatin-based chemotherapy . However, up to 30% of patients with advanced GCTs develop cisplatin-resistant disease, which requires intensive salvage treatment and has a 50% risk of cancer-related death ( 2 ) Primary mediastinal malignant germ cell tumor is rare and represents 1%-4% of mediastinal tumors, of which 50%-70% are nonseminomatous germ cell tumors (NSGCTs). Mediastinal NSGCT occurs almost exclusively in young males and it grows rapidly which often causes compression and invasion to mediastinal structures such as airway and major vessels Neurogenic tumors, thymomas, and developmental cysts account for about 60% of all mediastinal masses. Lymphomas and germ cell tumors such as teratoma and seminoma account for about 25%, and a large number of other lesions, both benign and malignant, constitute the remaining 15%. Table 83-5

Among germ cell tumors (GCTs), postpubertal primary mediastinal nonseminomatous germ cell tumors (PMNSGCTs) have the worse prognosis, with a 5-year survival rate of 45% to 50% in the most recent and largest series.1,2 This rare tumor represents only 1% of all primary mediastinal tumors, whereas only 1% to 5% of all GCTs are extragonadal, with the mediastinum being the most frequent location.2. Germ cell tumors are growths that occur in children, teens and adults. Germ cell tumors are rare, about 900 children and adolescents are diagnosed in the United States each year. They make up only 4% of all cancers in children and adolescents. Germ cell tumors most commonly appear in the gonads (sex organs). However, these tumors can arise in. Histiocytic proliferations associated with mediastinal nonseminomatous germ cell tumor (MNSGCT), ranging from hemophagocytic syndrome (HPS) to malignant histiocytosis (MH)/disseminated histiocytic sarcoma (HS), are very rare. The prognosis of these patients is extremely poor, with survival measured in months, despite various treatments. Statistical analysis of surrounding age from the yolk sac to the embryonic gonadal ridge. 14 Friedman 4 proposed that mediastinal germ cell tumors variables produced nearly significant P values. No other significant factors for survival were noted. originate from germ cells that were deposited in the thymus during embryogenesis. He also. Abstract. Background: Long-term relative survival (RS) data for testicular germ cell tumor (TGCT) patients are scarce. We aimed to analyze long-term RS among TGCT patients diagnosed in Norway, between 1953 and 2012. Methods: Data sources were the Cancer Registry of Norway and the Norwegian Cause of Death Registry. TGCT patients diagnosed during 1953 to 2012 were classified by time of diagnosis.

Mediastinal germ cell tumor - Wikipedi

Salvage Chemotherapy for Refractory Germ Cell Tumors. When relapse occurs in patients with germ cell tumors, two salvage treatment paradigms exist: standard-dose chemotherapy, or high-dose chemotherapy with autologous stem cell rescue. Most patients with germ cell tumors will be cured with local therapy and/or standard chemotherapy Most frequent germ cell tumor of the testis Presents in young men (30 - 49) with unilateral palpable mass Typically a well demarcated, uniform neoplasm with characteristic cytological features and background of fibrous septae and lymphocytes Germ cell markers (OCT 3/4, CD117) are useful in the diagnosi

Results of Superior Vena Cava Reconstruction With

Twelve male patients with mediastinal nonseminomatous germ cell tumors were treated with chemotherapy (with or without operation and radiation therapy) between 1963 and 1980. Eight patients, treated with only chemotherapy and radiotherapy, died with a median survival from diagnosis of 6 months (range, 3 to 12 months) Mediastinal germ cell tumors are uncommon tumors that occur predominantly within the anterior mediastinum and frequently present as a very large mass with local compression. Symptoms are typically vague and represent the local mass effects of the tumor. Chest computed tomography and examination of serum tumor markers provide the critical workup before a tissue diagnosis is obtained Outcomes of tandem transplant for primary mediastinal nonseminomatous germ cell tumors were generally poor compared to testes cancer, with a median survival of 11 months (range, 4-52 months). However, 3 of 12 subjects achieved a complete remission, 1 subject remained disease free at 50 months of follow up, and 1 remained free of disease. For malignant tumors, further studies on the clinical characteristics and genetic signatures on tumor samples might be necessary to better understand differences observed in high-risk patients and to assist the development of more effective treatment for this subgroup. KW - childhood. KW - germ cell tumors. KW - malignancies. KW - mediastinal. q 1997 American Cancer Society / 7b5e$$1249 12-25-97 21:35:12 canal W: Cancer 692 CANCER August 15, 1997 / Volume 80 / Number 4 T he existence of germ cell tumors arising primarily in the mediastinum has been known for well over a century.1 However, the existence of primary medias- controls were run concurrently for every antibody tested

Primary mediastinal germ cell tumors Primary mediastinal germ cell tumors Martini, Nael; Golbey, Robert B.; Hajdu, Steven I.; Whitmore, Willet F.; Beattie, Edward J. 1974-03-01 00:00:00 Thirty patients with germ cell tumors originating in the mediastinum are reviewed and analyzed (20 embryonal carcinomas and 10 seminomas). Local control of the disease was successful by resection and/or. Testicular ultrasonography (US) showed multiple, bilateral punctate echoes that are characteristic of TM. No primary testicular tumor was detected. Transthoracic needle biopsy of the mediastinal tumor was consistent with a mixed germ cell tumor. This is the seventh case of extragonadal germ cell tumor with TM Germ cell tumor of the testicle or, more rarely, the mediastinum or other extra-gonadal locations. Malignant neoplasm and is one of the most treatable and curable cancers, with a survival rate above 95% if discovered in early stages

Primary Mediastinal Germ Cell Tumors - CHES

mediastinal germ cell tumors: experience with 54 patients Ying Liu*, Zhou Wang, Zhong-Min Peng and Yang Yu Abstract Background: Primary malignant mediastinal germ cell tumor (PMMGCT) is rare and sometimes the prognosis of the patients with PMMGCT is not very satisfactory. Methods: A total of 54 patients with PMMGCT in a follow-up from 1990 to 2009 Discussion. Germ cell tumors are associated with a diverse histopathology and clinical prognosis. Approximately 20%-30% of patients with metastatic germ cell tumors have disease resistant to standard chemotherapy [], and 15%-20% of these tumors are incurable with the available treatments [].The optimal therapeutic approach for advanced germ cell tumors has not been established, and thus. The incidence and relative risk of coronary artery disease in patients with germ cell tumors who received chemotherapy, compared with germ cell tumor patients managed with surgery and surveillance alone, ranged from 5.7% to 6.7%, and from 1.35 to 7.1, respectively.[66,87-89] One study showed an increased risk of CVD mortality during the first. An international germ cell tumor prognostic classification has been developed based on a retrospective analysis of 5,202 patients with metastatic nonseminomatous germ cell tumors and 660 patients with metastatic seminomatous germ cell tumors. All patients received treatment with cisplatin-containing or carboplatin-containing therapy as their.

Mediastinal germ cell tumours Cancer Research U

1. The mediastinum is the most common site of extragonadal germ cell tumors. Mediastinal germ cell tumors account for only 2-5% of all germinal tumors, but they constitute 50-70% of all extragonadal tumors. Mediastinal germ cell tumors account for 1-15% of adult anterior mediastinal tumors Nivolumab in Platinum Recurrent or Refractory Metastatic Germ Cell Tumors The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government

Video: Mediastinal Nonseminoma - StatPearls - NCBI Bookshel

Spectrum of Germ Cell Tumors: From Head to To

PURPOSE OF REVIEW: The extragonadal germ cell tumors (EGCTs) represent a unique entity, and as such require specialized management. This review article will discuss the diagnosis, prognosis and treatment modalities for EGCTs. RECENT FINDINGS: The anterior mediastinal germ cell tumors (GCTs) are the most common EGCT. These tumors originate in the anterior mediastinum without any testis primary Small-cell carcinoma is a type of highly malignant cancer that most commonly arises within the lung, although it can occasionally arise in other body sites, such as the cervix, prostate, and gastrointestinal tract. Compared to non-small cell carcinoma, small cell carcinoma has a shorter doubling time, higher growth fraction, and earlier development of metastases